Yuzuriha Nekoi is a fourteen-year-old schoolgirl descended from the keepers of Mitsumine Jinja, masters of inugami (dog-spirits); their family name, which literally means "reliant on the cat", was deliberately chosen to conceal this.
A fan of sweets such as ice cream and Pocky (fictionalized as "Pooky" in the manga and "Rocky" in the anime), Yuzuriha is exceedingly energetic, often diffusing latent tension between Kamui and the rest of the Dragons of Heaven.
Yuzuriha's uncanny ability to allay Kamui's suspicions and earn his trust seems slightly tongue-in-cheek in that Yuzuriha essentially has dealt with wolf-like inugami her entire life, and Kamui's demeanor towards the rest of the Dragons of Heaven prior to Yuzuriha's appearance was rather wolfish—a play on Kamui's familial name.

Yuzuriha is attended by her own personal inugami, Inuki, who can shapeshift into anything she desires and who can only be seen by others with occult powers. She was teased throughout much of her childhood as her classmates believed Inuki was her imaginary friend. Because of this, Yuzuriha made a vow that she would never fall in love with (or even date) a man who could not see Inuki.
However, the first person outside of her family that she meets who can see Inuki is Kusanagi Shiyuu—a Dragon of Earth. Yuzuriha falls in love with Kusanagi, regardless of their conflicting fates.

Yuzuriha is, thus far, the only character who has effectively forced Fuuma Monou, the Kamui of the Dragons of Earth, to stand down in battle—a feat which many of the older and ostensibly more powerful Seals, such as Kamui and Subaru, have yet to come close to matching.
When Inuki is killed by one of the Dragons of Earth, she becomes greatly depressed, and Fuuma confronts her, prepared to grant her apparent wish to die; however, as he is forced to admit, her true wish is to live, and a new inugami (which she also names Inuki) is born from her heart.

At the end of the final episode, Yuzuriha is seen sitting by a waterfall with Inuki and Kusanagi (the same waterfall that the original Inuki led her to earlier in the series).
In the movie, however, Yuzuriha's relationship with Kusanagi is not acknowledged, and she is killed in a battle with Yuuto and Kusanagi while protecting Kamui.

In the X Tarot set, she represents Strength.

Voiced by: Yukana Nogami (Japanese) in the feature film

Voiced by: Kumi Sakuma (Japanese) in the TV series